技术平台

Platform for T Cell Receptor (TCR) T cell therapy

Technical Platform for T Cell Receptor (TCR) T cell therapy


T Cell Receptor (TCR) engineered T cell therapy starts from in vitro screening of tumor-neoantigen-specific T cells and cloning of the specific TCR genes. The TCR gene is then transduced into patient autologous T cells, and infused back into patients. These TCR-T cells could recognize tumor-neoantigen presented as the HLA-peptide complex, and then elicit downstream T cell activation signaling and eventually lead to tumor-specific lysis. 


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Currently, the company possesses a well-established TCR-T cell therapy platform, including high-specific targets, tetramer manufacture platform, high-throughput TCR screening and characterization platform, virus preparation system, TCR-T cell manipulation and functional evaluation platform. 



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Technical Procedure for TCR-T and CAR-T cells


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